Welcome to the CABS Parallel Programme

An Introduction to Cancer-Induced Bone Disease (CIBD)

A variety of neoplasms can strongly affect the integrity of the skeleton, leading to debilitating cancer-induced bone disease. The normal function of the bone/bone marrow compartment can be strongly affected by;

  • skeletal metastases (e.g. breast, prostate , lung, thyroid, bladder, kidney)
  • primary tumours at a distance (e.g. tumour-induced hypercalcaemia) and
  • primary bone tumors (osteosarcoma, Ewing sarcoma, chondrosarcoma)
  • haematological malignancies (multiple myeloma, leukaemia)

Cancer-induced bone disease represents a major clinical problem. For instance, incurable bone metastases develop in approximately 80 % of advanced breast and prostate cancer patients, leading to significant morbidity.  Moreover the treatment and management of patients with cancer-induced bone disease coincides with substantial medical costs.

CIBD at ECTS-IBMS 2015

The joint ECTS/IBMS conference offers a unique combination of expert state-of-the-art lectures, workshops, clinical debates, short talks, interactive poster sessions and satellite workshops for clinicians, basic scientists and translational researchers.

Novel mechanistic insights and novel therapies for skeletal metastasis, metastatic bone disease and primary bone tumours will be presented and discussed during the dedicated CIBD parallel programme that can be attended as part of the overall ECTS-IBMS 2015 registration fee.

Please register for the CABS Parallel Programme by ticking the relevant box during main online registration process: Click here to register now!

CIBD Parallel Scientific Programme

Sunday 26 April 2015

08:00 - 10:00       Break-out Session 1: Tumor Microenvironment: The Dark Side of the Bone

08:00 - 08:30       Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

                          Anjali Kusumbe (Münster, Germany)

08:30 - 09:00       Molecular stromal signatures in the supportive bone microenvironment of breast and prostate cancer

                          Janine Hensel (Bern, Switzerland)

09:00 - 10.00       Short Talks 1 - 6

11:00 - 12:15       Break-out Session 1 continued

11:00- 11:30       Bone and hematopoietic stem cells: partners in leukemogenesis?

                           Mark H. Raaijmakers (Rotterdam, The Netherlands)

11:30 - 12:00     The Bone Microenvironment and Myeloma

                           Nicola Guiliani (Parma, Italy)

12:00 - 12:15       Short Poster Talks 1-3

Monday 27 April 2015

11:00 - 12:30       Break-out Session 2: New Therapies & Approaches in Cancer-induced Bone Disease

11:00 - 11:30       Radium223 and skeletal metastases

                           Øyvind S. Bruland (Oslo, Norway)

11:30 - 12:00       Preclinical developments; Radium223 in osteolytic bone metastases and osteosarcoma?

                          Michel Wissing (Leiden, The Netherlands).

12:00 - 12:30       Clinical Debate: ‘Radium-223 can augment the efficacy of cancer and bone treatments   for metastatic bone disease!’

                           Chair: Rob Coleman (Sheffield, UK)

                           Janet Brown (Sheffield, UK) & Luis Costa (Lisbon, Portugal)                                                                                                                        

14.30 - 16.45       Break-out Session 3: Cancer Plasticity, Stem Cells and Dissemination

14:30 - 15:00       Mechanisms of cancer invasion and metastasis: potential therapeutic implications

                          Peter Friedl (Nijmegen, The Netherlands & Houston, USA)

15:00 - 15:30       Breast stem cells and cancer

                          Rob Clarke (Manchester, UK)

15:30 - 16:00       CTCs, who cares? It’s all about DTCs!

                          Ingunn Holen (Sheffield, UK)

16:00 - 16:20       Short Talks 1 - 2

16:20 - 16:45       Short Poster Talks 1 - 5

Tuesday 28 April 2015

08:00 - 10:00       Break-out Session 4: Noncoding RNAs in Tumor Progression and Cancer-induced Bone Disease

08:00  - 08:30      Long non-coding RNAs in Prostate Cancer Progression

                          Guido Jenster (Rotterdam, The Netherlands)

08:30  - 09:00      Short Talks 1 - 3

09:00 - 09:30       MicroRNA-dependent and epigenetic programs in osteosarcoma development

                          Thibaut Quillard (Nantes, France)                                                                                                        

09:30 - 09:55       Short Poster Talks 1 - 5